Mathematical modeling of chemotherapy strategies in vascular tumor growth using nanoparticles

Drug release kinetics at the tumor site is an important aspect of chemotherapy. Nanoscale devices carrying chemotherapeutic drugs could extravasate from blood vessels and even diffuse through the tissue and enter tumor cells. Drug delivery through Nanoparticles (particles between 10 nm and 1000 nm in size) presents significant potential advantages over traditional delivery via bolus injection. It is expected that chemotherapy involving nanotechnology will be more effective in targeting malignant cells and sparing healthy tissue. In this paper, we have developed a mathematical model that describes the drug delivery in a vascular tumor using the Nanoparticles on the order of 10 nm and 100 nm.